Endocrine system changes with aging
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It seems plausible to expand the role of the endocrine system to explain the gradual changes in body structure and function that take place with age because the endocrine glands play crucial roles in both reproduction and development (senescence). In fact, a "endocrine theory of ageing" was very well-liked in the past. However, it is now known that, with some exceptions, endocrine function does not alter considerably with age. The most significant modification is the sudden decline in ovarian function that occurs after menopause. Melatonin, growth hormone, insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone production all experience age-related declines over time (DHEA). After these declines were noticed, the idea that administering these hormones would possibly slow down the ageing process emerged. The injection of these or any other hormones, however, does not appear to lessen or even reverse any of the biological changes associated with ageing, according